Nrf2 and Skin Health

The proven science behind Nrf2's skin-protecting benefits

How can Nrf2 benefit you?

  • Minimizes inflammation, irritation and redness
  • Reduces wrinkles and improves skin tone
  • Safeguards against free radical/oxidative stress
  • Protects against UV radiation exposure
  • Maintains integrity of key skin structural components
  • Minimizes risk of skin cancers and other skin-related conditions

Our Skin Reflects Our True Health

You’ve heard the old saying, “Beauty is more than skin deep” – and it’s true – especially when you realize that our body has a built-in “beauty protection” network inside of every cell, including our skin cells. You’ll often hear that the skin has “two layers” (the dermis and epidermis), but the epidermis (uppermost layer) is actually comprised of five distinct layers and the dermis (deeper layer) has two different layers – so our skin actually has seven different layers that protect our delicate (internal) tissues from the damaging (external) environment.

Emerging science is discovering a new approach to caring for your skin, one that addresses what goes on inside you and at the deeper layers of skin (not just the surface) in order to bring forth the most glowing, clear, healthy skin on your outside. Achieving healthy, beautiful skin is truly an inside-out process. Looking better, feeling better, having more confidence, and causing your exterior to reflect your beautiful interior (and vice versa) is what the latest skin science is all about.

Nobody wants to look like they’re aging. Americans spend hundreds of millions of dollars every year on lotions, creams, and coatings to be applied to the surface of the skin (the dead part, called the stratum corneum). Many of these concoctions do a wonderful job of smoothing out wrinkles and giving the appearance of younger, healthier skin. The illusion of healthier skin, however, rapidly fades when the beauty cream wears off.

Nrf2 Offers Multi-Faceted Skin Solution

What we perceive as “aging” is actually a complicated and multifaceted phenomenon related to skin breakdown and repair—a cyclical process that we scientists refer to as “tissue turnover.” In the case of skin, we call it “collagen turnover.” The most effective solution to a multifaceted problem is a multifaceted solution, and that’s exactly what topical Nrf2 activation is all about.

Today, the scientific community accepts the fact that chronic cellular stress leads to a rapid breakdown in a variety of tissues, including skin. Cellular stress in skin cells inevitably leads to skin problems, such as wrinkles, acne, and uneven skin tone. Nrf2 regulates our body’s response to cellular stress and numerous studies have shown that both topical and internal/systemic activation of the Nrf2 pathway can have a wide range of beneficial effects on skin, including reduced rates of skin cancers, protection from ultraviolet radiation, reduced inflammation, enhanced barrier function, and improved wound healing.

The Science Behind Nrf2's Cancer-Protective Benefits Skin Cancer

Study 1

In a series of human clinical studies and laboratory studies (isolated skin samples and DNA analysis) using “enhanced Nrf2 technology” (eNt), a synergistic blend of natural Nrf2 activators (extracts of bacopa, milk thistle, turmeric, green tea, black pepper, brassica, and plantain) has been shown to improve skin tone, reduce wrinkles, and generally enhance youthful appearance.

Study 2

In a series of human clinical studies (86 women) conducted by Canadian researchers, topical application of the eNt blend (twice daily for 4-8 weeks) resulted in dramatic improvements in key beauty benefits, including an extremely high percentage of women who felt that their skin was improved in the following ways: looking smoother (94%), younger (87%), firmer (85%), more even tone (83%), and with fewer wrinkles (82%).


Study 3

American researchers performed a follow-up human clinical study (27 men) investigating the skin health benefits of the specific eNt blend used as part of a shaving regimen. After only 7 days, users of the eNt-based shaving regimen showed significant and dramatic improvements in skin barrier function and irritation/inflammation – indicating that topical activation of the Nrf2 pathway with eNt was effective in not only protecting the skin from the damaging effects of shaving (mechanical stress), but also improving the health of the skin.

Study 4

In a series of laboratory studies, isolated skin samples (explants) were investigated to understand the biochemical and genetic mechanisms underlying such rapid and dramatic clinical benefits, French researchers treated isolated skin samples daily with the specific eNt blend. Findings showed clear evidence of the eNt blend to:

  • Increase Nrf2 protein levels in skin (thus improving biochemical resistance to oxidative stress)
  • Boost skin protection from ultraviolet light exposure (by reducing genetic DNA damage)
  • Fight the signs of aging through all layers of the skin
The future of science and medicine is targeting the Nrf2 pathway to not only protect our health, but also to actively improve how we feel/look/perform. Nrf2 activation, especially when optimally synergistic in nature, allows you to enjoy enhanced anti-aging benefits for a new level of wellness and vitality.

Retinol Facial Cream for 7 Days

6 to 7 layers with damaged and bloated cells & pyknotic nucleus (condensed chromatin)

Nrf2 Facial Cream for 7 Days

6 to 7 cell layers with good morphology and organization denser dermis